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Tacroz® Forte Ointment

Tacroz® Forte Ointment

Tacroz® Forte Ointment is an immunomodulatory medication used to relieve inflammatory skin conditions caused by certain diseases such as atopic dermatitis and Vitiligo. Applied to the skin, it performs anti-itching, healing, and anti-inflammatory activities.  Show full description

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Tacroz® Forte Ointment (Tacrolimus) 0.1%, 10 g

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Description

Tacroz® Forte Ointment is manufactured by Glenmark. This is an immune response modifier used to relieve manifestations of inflammatory skin conditions including atopic dermatitis (AD) among others. Tacroz® Forte Ointment comprises Tacrolimus as an active ingredient. Tacrolimus is a сalcineurin inhibitor and immunosuppressive non-antibiotic macrolide. In topical administration, it is effective against certain autoimmune disorders due to its immunomodulatory, anti-pruritic, and anti-inflammatory properties.

Tacroz® Forte Ointment is used when treatment is not responsive to conventional therapy such as topical corticosteroids.

Indications:

- moderate to severe atopic eczema (also known as atopic dermatitis);

- severe refractory uveitis after bone marrow transplants;

- Vitiligo.

MOA (mechanism of action):

Tacrolimus suppresses cell-mediated immune reactions. It acts by inhibiting the activation of lymphocytes (T-cells), main components of an immune response against the body's own proteins. Deactivating the lymphocytes, Tacrolimus suppresses the immune system and neutralizes inflammatory symptoms caused by abnormal immune reaction (itching, redness, swelling, etc.). Tacrolimus also suppresses inflammatory genes in immune cells.

Dosage

Apply Tacroz® Forte Ointment twice a day until the clearance of skin lesions (no longer than 6 weeks).

Continue to apply the ointment to the commonly affected areas twice a week for up to 12 months after your skin has cleared (for prophylaxis). There should be 2 or 3-day break between the applications.

Do not use Tacroz® Forte Ointment for more than 12 months.

Avoid swallowing or getting in/around your eyes, lips, on mucosal surfaces or to your back passage and private parts. If it does get there, wash with water.

How to use Tacroz® Forte Ointment:

1. Ensure the application site is clean and dry before applying Tacroz® Forte Ointment.

2. Apply a thin layer of Tacroz® Forte Ointment to the frequently affected areas with clean dry hands.

3. You can apply Tacroz® Forte Ointment to most areas of skin on your body except lips, inside of the nose, around the eyes, and any mucous surface.

4. Avoid covering the treated skin with tight bandages or wraps.

5. If you want to apply any cream or moisturizer to the Tacroz® Forte Ointment treated area, wait for 2 hours after the ointment application.

6. Wash your hands after you have applied the Tacroz® Forte Ointment (unless your hands are being treated).

Consult your doctor on how often to apply Tacroz® Forte Ointment. Use Tacroz® Forte Ointment exactly as directed.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not apply a double dose.

Overdose

Do not exceed the doctor's recommended dose. If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at a room temperature from 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away the tube after the expiration date. Keep away from children.

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Side effects

The most common side effects associated with the use of Tacroz® Forte Ointment are:

  • allergic reactions (hives, difficult breathing, swelling of your face, lips, tongue, or throat)
  • irritation, redness or rash
  • burning and itching at the application side
  • thinning of the skin
  • increased skin sensitivity to heat and cold
  • tingling
  • local skin infections (e.g. cold sores)
  • infected hair follicles (folliculitis)

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Do not apply Tacroz® Forte Ointment if you are allergic to Tacrolimus or any other macrolide.

Do not apply Tacroz® Forte Ointment if you are allergic to any of the other ingredients comprised in Tacroz® Forte Ointment.

Do not apply Tacroz® Forte Ointment if you have a history of severe allergic reactions associated with using macrolides.

Do not take by mouth. Tacroz® Forte Ointment is for use only on the skin.

Do not use Tacroz® Forte Ointment if you have a skin barrier defect, such as Netherton's syndrome, lamellar ichthyosis, generalized erythroderma, cutaneous Graft Versus Host Disease, or infected skin.

Do not use in patients under 16 years old.

Do not apply more Tacroz® Forte Ointment than the amount prescribed for you.

Do not use the Tacroz® Forte Ointment if it has already expired.

Exposure of the sunlight to the skin should be minimized during Tacroz® Forte Ointment treatment course. Use sunscreen and cover the skin with appropriate clothing.

Covering the treated skin with occlusive bandage in not recommended.

Consult your doctor if you are pregnant. Tacroz® Forte Ointment should be used during pregnancy only if clearly needed.

Do not breastfeed during Tacroz® Forte Ointment usage.

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Frequently asked questions

Q: Is it safe to breastfeed during Tacroz® Forte Ointment usage?

A: No. You should not use Tacroz® Forte Ointment during lactation, as its active ingredient Tacrolimus transmits to the breast milk.

Q: Is Tacroz® Forte Ointment a steroid?

A: No. Tacroz® Forte Ointment is an immunomodulatory agent based on Tacrolimus – non-antibiotic macrolide.

Q: Is it safe to apply Tacroz® Forte Ointment to the face?

A: Yes. It is completely safe to apply Tacroz® Forte Ointment to the face as far as you avoid getting it in/around your eyes, lips, and inside of the nose.

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