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Supatret® Gel

Supatret® Gel

Supatret® Gel is a topical treatment for acne. This is a retinoid formulation with strong anti-acne and exfoliating properties. Supatret® Gel is developed for use in adults and children over 10 years of age.  Show full description

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Other names for this medication

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Supatret® Gel (Tretinoin) 0.04%, 20 g

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Description

Supatret® Gel is manufactured by Sun Pharma. This is a topical medication for acne (also known as acne vulgaris). It has anti-inflammatory and exfoliating properties. Applied to the acne-prone skin, Supatret® Gel reduces the number of breakouts and unclogs blocked pores. The active substance of this gel is Tretinoin, vitamin A (retinol) derivative of retinoid class.

Acne is a long-term inflammatory skin condition caused by an overgrowth of P. acnes (Propionibacterium acnes) in the skin. When there is too much sebum (skin oil) produced, it mixes with dead skin cells residue and clogs pores. The clogged pore is a positive environment for P. acnes proliferation. Our immune system responds to the abnormal amount of P. acnes with acne progression. Symptoms of this condition are comedones, whiteheads, pimples, cysts, and scarring. Genetic predisposition and increase in androgen hormones are among the most common reasons of acne.

Supatret® Gel in higher dosage (0.1%) is used to treat photoaging, fine wrinkles, and facial skin roughness. It is also can be used off-label to treat melasma, actinic keratosis, ichthyosis, keloids, and keratosis follicularis.

MOA (mechanism of action):

Tretinoin is a comedolytic, keratolytic, and anti-inflammatory agent. It fights acne by unclogging blocked pores, where P. acnes bacteria grow and live. In particular, it modifies the abnormal follicular keratinization and promotes the turnover rate of dead epithelial cells (constituents of the outermost skin layer). With the exfoliation of keratinized skin cells, the content of blocked pores releases and acne-causing bacteria have no longer an environment to proliferate in, therefore inflammation starts decreasing and disappears with time. Tretinoin also makes epithelial cells divide faster causing the comedones to be pushed out of the blocked pores more rapidly.

Dosage

Supatret® Gel is for external use only. Do not apply to your eyes, mouth, inside of the nose, private parts, and any other mucosal surface.

Supatret® Gel is normally applied 1-2 times daily, usually for 6-8 weeks at least. In case your acne has not improved after 8 weeks of treatment, discontinue the Supatret® Gel use and seek medical advice.

How to use Supatret® Gel:

1. Wash your hands and the affected areas with mild soap or cleanser, pat dry.

2. Apply a thin layer of the gel to the affected areas with your finger tips or a cotton wool.

3. Gently rub until the gel is mostly absorbed.

4. Wash your hands after the gel application.

Precautions

Do not let Supatret® Gel collect in folds of the skin, such as where your nose meets your face.

Do not apply Supatret® Gel to the irritated, itchy, cracked or burnt skin (sunburns and windburns included).

Do not apply Supatret® Gel to the open wounds or cuts.

Do not cover the Supatret® Gel application site with occlusive bandages or other covering.

Do not use Supatret® Gel in combination with harsh skin products, medicated soaps and shampoos, products with drying effect on the skin, peeling agents, products containing alcohol, spices or lime.

Do not get permanent wave solutions and waxing products on skin being treated with Supatret® Gel.

Do not apply skin moisturizers or makeup to the skin being treated with Supatret® Gel 1 hour before and after the gel application.

Patients should use sunscreens (min. SPF 15) and protective clothing while using Supatret® Gel.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not apply a double dose.

Overdose

Do not exceed the doctor's recommended dose. If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at a room temperature from 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away the tube after the expiration date. Keep away from children.

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Side effects

The most common side effects associated with the use of Supatret® Gel are:

  • itchy skin
  • burning or stinging sensation
  • redness
  • scaling
  • skin rash
  • contact dermatitis
  • exacerbation of the psoriasis
  • dry skin

Side effects occurrence does not only depend on the medication you are using, but also on your overall health and other factors.

Contraindications

Do not apply Supatret® Gel if you are allergic to Tretinoin.

Do not apply Supatret® Gel if you have a history of severe allergic reactions associated with the use of retinoids or Vitamin A.

Do not apply Supatret® Gel if you are allergic to any of the other ingredients comprised in Supatret® Gel.

Do not use Supatret® Gel if you or any of your family members have ever had an epidermal tumor.

Do not use Supatret® Gel if you are taking any pain medications (aspirin, ibuprofen, meloxicam, tramadol), asthma drugs (albuterol), antibiotics (clindamycin, doxycycline, minocycline), omega-3 polyunsaturated fatty acids (fish oil), muscle relaxers (cyclobenzaprine), corticosteroids (fluticasone, prednisone), epilepsy drugs (gabapentin, clonazepam), hormones (melatonin), stomach drugs (omeprazole), antidepressants (trazodone, alprazolam) or antihistamines (cetirizine).

Do not use Supatret® Gel if you have eczema, rosacea, hepatic disease or perioral dermatitis.

Do not use Supatret® Gel if you have skin cancer, skin photosensitivity disorder, sunburn or sunlight (UV) exposure.

Do not use Supatret® Gel in combination with any other acne medications.

Do not apply Supatret® Gel if you have sunburn, windburn or skin irritation with redness, peeling or itching.

Do not use Supatret® Gel in children under 10 years of age.

Supatret® Gel is strictly prohibited in women who are pregnant, plan to have a baby or are breastfeeding.

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Frequently asked questions

Q: Can I treat rosacea with Supatret® Gel?

A: No. Supatret® Gel is contraindicated for patients having rosacea and it should be used only to treat acne.

Q: Is it safe for teenagers to use Supatret® Gel?

A: Supatret® Gel is completely safe for the use in patients over 10 years of age.

Q: Can Supatret® Gel be used in pregnant women?

A: Supatret® Gel is strictly prohibited in women who are pregnant, plan to have a baby or are breastfeeding.

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